Nexvenla OD Plus Tablet 
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NOTICE: unsafe with : Alcohol
USED FOR:
Depression
Short term anxiety
COMPOSITION:
Desvenlafaxine (50mg)
Clonazepam (0.5mg)
Therapeutic Uses:
neuro cns
CAUTION
Nexvenla OD Plus Tablet may cause excessive drowsiness and calmness with alcohol.
WEIGH RISKS VS BENEFITS
Nexvenla OD Plus Tablet is unsafe to use during pregnancy.There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
CAUTION
Nexvenla OD Plus Tablet is probably unsafe to use during lactation. Limited human data suggest that the drug could represent a significant risk to the baby.
Nexvenla OD Plus Tablet may cause side effects which could affect your ability to drive.
Nexvenla OD Plus Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Nexvenla OD Plus Tablet may not be needed in these patients. Please consult your doctor.Use of Nexvenla OD Plus Tablet can cause excessive sleepiness in patients with end stage kidney disease.
CAUTION
Nexvenla OD Plus Tablet should be used with caution in patients with liver disease. Dose adjustment of Nexvenla OD Plus Tablet may be needed. Please consult your doctor.
Uses of Desvenlafaxine
Desvenlafaxine is used in the treatment of depression.
How to use Desvenlafaxine
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nexvenla OD Plus Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Nexvenla OD Plus Tablet works
Desvenlafaxine works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance.
Common Nausea, Vomiting, Dizziness, Anxiety, Increased sweating, Insomnia (difficulty in sleeping), Constipation, Decreased appetite, Sexual dysfunction.
Expert advice for Desvenlafaxine
You may have to wait for 2 to 4 weeks to get the full effect. If your doctor asks you to stop Desvenlafaxine, you should not discontinue it abruptly. Many patients tolerate decreasing 50% dose every 3 days however if the withdrawal symptoms emerge during tapering it would require more gradual tapering over few weeks. Inform your doctor if you have ever been diagnosed with any heart problems (heart attack, heart failure, slow or irregular heart rate). Inform your doctor if you have ever been diagnosed with kidney or liver problems. It can cause a sensation of restlessness or an inability to sit or stand still. This is most likely to occur within the first few weeks of treatment. You should tell your doctor if this happens to you. It may be more effective in some patients with depression who fails to respond to selective serotonin receptor inhibitors (SSRI) e.g. Fluoxetine.
Q. Is Desvenlafaxine a narcotic?
No. Desvenlafaxine is not a narcotic drug. Narcotics are drugs with sleep inducing properties, usual derivatives of Opium like Heroin and Morphine.
Q. What is the difference between Desvenlafaxine ER or Desvenlafaxine succinate?
Desvenlafaxine ER or XR both means extended release preparation which releases the medication slowly into the body and maintains a constant needed medications levels. The advantage of taking ER/XR tablets is the frequency of dosage can be decreased.
Q. How to wean Desvenlafaxine?
Weaning of Desvenlafaxine can be done by a gradual reduction in the dose rather than abrupt cessation is recommended whenever possible. Abrupt cessation of the therapy leads to a lot of adverse effects.
Q. How is Desvenlafaxine different from venlafaxine?
Desvenlafaxine is an active metabolite of venlafaxine. It is the same medication in an active form.
Q. How is Desvenlafaxine works?
Desvenlafaxine is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI). Desvenlafaxine is thought to be related to the potentiation of the neurotransmitters in the central nervous system.
Q. When to take Desvenlafaxine?
Take Desvenlafaxine exactly as advised by your doctor. Take Desvenlafaxine at about the same time each day with or without food. Swallow Desvenlafaxine tablets in whole, with fluid. Do not crush, cut, chew, or dissolve the tablets because the tablets may be time-released.
Q. Can Desvenlafaxine be switched to sertraline?
Yes. It can be switched but discontinuation symptoms are common while changing the therapy. So, tapering of the antidepressant may be necessary to minimise discontinuation symptoms. The switch over of the therapy from Desvenlafaxine should be done by the doctor. Do inform your doctor about all your present medications before starting the therapy.
Q. Are there any alternatives to Desvenlafaxine?
Yes. There are many alternatives to Desvenlafaxine. You should use the alternative under the guidance of your doctor.
Q. Is Desvenlafaxine good medication for anxiety?
Desvenlafaxine can be taken in anxiety and panic disorders. It is also used for the treatment of depression.
Q. Does Desvenlafaxine cause sedation?
Yes. Desvenlafaxine is known to cause sedation. Do not take this medication with other sleep inducing drugs it may lead to excess sleepiness, drowsiness, decreased concentration and difficulty in work. Consult your doctor before starting this medication.
Q. Does Desvenlafaxine be used to treat menopausal vasomotor symptoms?
Desvenlafaxine is approved for treatment of depression but few types of research have shown the efficacy of desvenlafaxine in the treatment of hot flashes.
Q. Can Desvenlafaxine be used in the treatment of irritable bowel syndrome (IBS)?
Desvenlafaxine is not approved for the treatment of IBS. It is approved for treatment of depression but few types of research have shown the efficacy of desvenlafaxine in the treatment of IBS.
Q. Can I use Desvenlafaxine for depression?
Yes. Desvenlafaxine is a medication approved for the treatment of depression. Do not start Desvenlafaxine by yourself. Consult your doctor before starting this medication.
Q. Can I use Desvenlafaxine for a migraine?
No. Desvenlafaxine is approved for treatment of a migraine. It is used in the treatment of depression.
Q. Can hot flashes be treated with Desvenlafaxine?
Desvenlafaxine is not approved for treatment of depression but few types of research have shown the efficacy of desvenlafaxine in the treatment of hot flashes.
Q. Can I use Desvenlafaxine for social anxiety?
Desvenlafaxine is approved for treatment of depression but few types of research have shown the efficacy of desvenlafaxine in the treatment of social anxiety.
Q. Can neuropathic pain be treated with Desvenlafaxine?
Desvenlafaxine is not approved for treatment of neuropathic pain. It is an antidepressant. It is used off-label for treatment of neuropathic pain.
Q. Which medication is best, Desvenlafaxine or escitalopram?
Both are antidepressant medication and the therapy is decided by the type of patient, however, some studies show escitalopram is almost similar to Desvenlafaxine.
Q. Can I take tramadol along with Desvenlafaxine?
No. Tramadol should be absolutely avoided with Desvenlafaxine. They both cause an increase in the levels of serotonin in the body increasing the chances of potentially life-threatening serotonin syndrome.
Q. Can venlafaxine be switched to Desvenlafaxine abruptly?
No. You should not change or switch over to any other drug. It may lead to various adverse effects called as discontinuation symptoms. Talk to your doctor if you are not comfortable with Desvenlafaxine and it should be tapered slowly and then stopped.
Q. What should I avoid while taking Desvenlafaxine?
You should avoid taking any other antidepressants medications, medicines to treat migraine headaches known as triptans,medicines used to treat mood, anxiety, psychotic, or thought disorders, including tricyclics, lithium, selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), antipsychotic drugs, or other dopamine antagonists, such as metoclopramide.
Q. How long should I continue taking Desvenlafaxine?
Desvenlafaxine is an antidepressant medication. These medications are to be taken for a long duration of months or year. The exact duration of treatment is decided by the improvement of the symptom.
Q. Will Desvenlafaxine affect my sex drive?
There are few cases reports to suggest that it effect sex drive but not all patients suffer from that.
Uses of Clonazepam
Clonazepam is used in the treatment of short term anxiety, alcohol withdrawal and epilepsy.
How to use Clonazepam
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nexvenla OD Plus Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Nexvenla OD Plus Tablet works
Clonazepam is a benzodiazepine. It works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.
Common Sleepiness, Uncoordinated body movements, Slurred speech, Dizziness, Fatigue, Memory impairment, Irritability, Headache, Dryness in mouth, Depression, Constipation.
Expert advice for Clonazepam
If you are taking Clonazepam for the treatment of insomnia and anxiety, it should not be used more than 4 weeks. It may become less effective over the time. It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery. Avoid consuming alcohol when taking the Clonazepam, as it may cause excessive sleepiness or drowsiness. Inform your doctor if you are pregnant or planning to conceive or breastfeeding. Inform your doctor if you have ever been diagnosed with kidney or liver problems. The addiction / habit-forming potential of Clonazepam is very high.
Q. Can I take Clonazepam while taking a dietary supplement?
It depends on what kind of dietary supplement it is. Normally absorption of Clonazepam is not affected by food and other vitamins. Consult your doctor before you start taking the medication.
Q. Which medication is best, alprazolam or Clonazepam?
Both are equally effective as suggested in different research studies.
Q. What is the difference between clotiazepam and Clonazepam?
Clotiazepam is a benzodiazepine which has anxiolytic, sedative and antiepileptic property. It differs from other benzodiazepines (Clonazepam) in that the benzene ring is replaced by thiophene ring. Clinical use of clotiazepam is relatively low.
Q. Which medication is best, lorazepam or Clonazepam?
Both are equally effective as shown in the research studies.
Q. Which medication is best, diazepam or Clonazepam?
Both are equally effective as shown in the research studies.
Q. Can Clonazepam affect my sex drive?
There are few reports but it is not so common. Clonazepam does not affect the sexual drive in all the patients.
Q. Is Clonazepam a narcotic?
No. Clonazepam is not a narcotic. Narcotics are drugs with sleep inducing properties, usual derivatives of Opium like Heroin and Morphine.
Q. Is Clonazepam muscle relaxant?
Clonazepam is approved for the treatment of anxiety, alcohol withdrawal and epilepsy. Some research studies have shown it has got muscle relaxant properties.
Q. Can I take vitamin B along with Clonazepam?
There is no known major interaction found with vitamin B when taken with Clonazepam.
Q. Can I take vitamin C along with Clonazepam?
There is no known major interaction found with vitamin C when taken with Clonazepam.
Q. Can I take Clonazepam while I am on hepatitis C treatment?
The treatment of hepatitis C includes many drugs and the side effects depends on which drug you are prescribed.
Q. Can Clonazepam cause euphoria?
No. Clonazepam does not cause euphoria. It causes sleepiness, dizziness etc.
Q. Can Clonazepam get you high?
Clonazepam does not make you feel high.
Q. Can Clonazepam be replaced with paroxetine?
No. both are different medication. Clonazepam is an antianxiety, anticonvulsant drug whereas Paroxetine is an antidepressant medication
Q. Can Clonazepam cause rash?
Clonazepam is not commonly known to cause a rash but hypersensitive individuals can develop a rash.
Q. Is Clonazepam the best choice for restless legs syndrome?
There are other treatment modalities for restless leg syndrome but among these benzodiazepine class of drug Clonazepam is most studied drug. It is not approved for restless leg syndrome but used off label.
Q. How is bupropion different than Clonazepam?
Bupropion is in the treatment of depression and for smoking cessation. Clonazepam is an anti-seizure and anti-anxiety medicine.
Q. Can I take Clonazepam along with zolpidem?
No. You should avoid taking these two medications together. They both induce sleep and taking them together can lead to increased sleepiness, decreased concentration, ataxia and abnormal co-ordination.
Q. Which medication is better, Clonazepam or clobazam?
Clobazam causes less sedation as compared to Clonazepam as seen in few research studies.In few studies, clobazam showed a good retention when given for a longer period whereas Clonazepam needs a dose escalation.
Q. Can I take Clonazepam along with fluoxetine?
You should avoid taking these two drugs together as they increase side effects like sleepiness, dizziness, drowsiness, confusion, and difficulty concentrating.
Q. Can I take Clonazepam while I am also taking antibiotics?
It depends on which antibiotics you are on treatment. Consult your doctor before starting these medications.
Q. Can I take Clonazepam along with escitalopram?
You should avoid taking these two drugs together as they increase side effects like sleepiness, dizziness, drowsiness, confusion, and difficulty concentrating.
Q. Which medication is better, Clonazepam or nitrazepam?
Both are equally effective as shown in the research studies.
Q. Can I take Clonazepam along with paracetamol?
Yes. You can take prescribed doses of paracetamol with Clonazepam. Inform your doctor if you have any allergy or liver problems before starting these medications.
Q. Which is stronger Clonazepam or oxazepam?
We could not find any direct studies comparing Clonazepam with oxazepam. However, oxazepam is an intermediate-acting benzodiazepine with a slow onset of action.
Q. Which medication is better Clonazepam or etizolam?
Etizolam is a short acting drug and its structure is a bit different from the benzodiazepines class of drugs. Both are used in inducing sleep and relieving anxiety however it depends.
Q. When does Clonazepam expire?
The expiry date of Clonazepam is given on the tablet strip and provided by the manufacturer.
Q. How does Clonazepam affect the brain?
Clonazepam works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.
Q. Can I take Clonazepam along with coffee?
Yes. There are no major interactions known between coffee and Clonazepam.
Q. What is the difference between Clonazepam and zopiclone?
Clonazepam is an anti-siezure, antianxiety medication. Zopiclone is a sedating drug from different class and it is only used for inducing sleep
Q. What is the difference between Clonazepam and olanzapine?
Clonazepam is an anti-seizure, antianxiety medication. Olanzapine is an atypical antipsychotic medication.
Q. Can Clonazepam cause low blood pressure?
Clonazepam is not known to cause low blood pressure commonly. It can cause palpitation in some patients.
Q. Can I use Clonazepam for sciatica?
No. Clonazepam is not a known medication for sciatica. It is an antiseizure, antianxiety medication.
Q. Can tremors be treated with Clonazepam?
Clonazepam is not an approved drugs for treatment of tremors. However, in some research studies, it has been shown Clonazepam is effective
Q. Can I use Clonazepam for nausea?
No. Clonazepam is not a medication for nausea. It is an antiseizure, antianxiety medication.
Q. Can I use Clonazepam for a headache?
No. Clonazepam is not a medication for a headache. It is an antiseizure, antianxiety medication.
Q. Can I use Clonazepam for vertigo?
No. Clonazepam is not a medication for vertigo. It is an antiseizure, antianxiety medication. However, few studies have shown its effectiveness in vertigo.
Q. Can insomnia be treated with Clonazepam?
Yes. Though Clonazepam is not approved for treatment of insomnia. Clonazepam is used off-label for the treatment of sleep disorders.
Q. Can I use Clonazepam for depression?
No. Clonazepam is not a medication for depression. It is an antiseizure and antianxiety medication. There are the different class of drugs for treating depression.
Q. Can I use Clonazepam in pain management?
No. Clonazepam is not a medication for management of pain disorders. It is an antiseizure and antianxiety medication. There are the different class of drugs for treating pain. Few studies have failed to prove the effectiveness of Clonazepam in pain management.
Q. What is the good time to take Clonazepam?
It is given mostly at night as it causes sedation.
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